By M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)
Cytotoxic T lymphocytes (CTL) keep an eye on a number of viral infections in animals in accordance with deletion and reconstitution experiments with CTL clones and use of CD8 genetically poor (knock-out) mice. during this quantity, information for the position that CTL play in human infectious illnesses is gifted. As such, this represents the 1st quantity during which such info from numerous various viral and protozoan infections is introduced together.
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Extra resources for Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections
J Infect Dis 153: 478-488 Meyers J 0, Bowden RA Counts GW (1987) Infections after bone marrow transplantation. In: Lode H, Huhn 0, Melzahn M (eds) Infections in transplant patients. Thieme, Stuttgart. pp17-32 Meyers JD, Ljungmann P, Fisher LD (1990) Cytomegalovirus excretion as a predictor of cytomegalovirus disease after marrow transplantation: importance of cytomegalovirus viremia. J Infect Dis 162: 373-380 Moore MW, Carbone FA. Bevan MJ (1988) Introduction of soluble protein into the class I pathway of antigen processing and presentation.
We wish to thank William Britt, University of Alabama (Birmingham), for providing the vaccinia/CMV recombinant viruses. References Borysiewicz LK, Morris S, Page J, Sissons JG P (1983) Human cytomegalovirus-specific cytotoxic T lymphocytes: requirements for in vitro generation and specificity. Eur J Immunol 13:804-809 Borysiewicz LK, Graham S, Hickling JK, Sissons JG P (1988a) Precursor frequency and stage specificity of human cytomegalovirus-specific cytotoxic T cells. Eur J Immunol18: 269-275 Borysiewicz LK, Hickling JK, Graham S, Sinclair J, Cranage MP, Smith GL, Sissons JGP (1988b) Human cytomegalovirus-specific cytotoxic T cells: relative frequency of stagespecific CTL recognizing the 72 KD immediate early protein and glycoprotein B expressed by recombinant vaccina viruses.
Studies of murine influenza-specific CTl demonstrated that CTl were able to recognize the highly conserved internal nucleoprotein (TOWNSEND et al. 1984), and subsequent studies have shown that the nucleoprotein is the major target for cross-reactive CTl in this infection (YEwDELL et al. 1985). Although the observation that viral proteins such as the influenza nucleoprotein that are not expressed on the cell may serve as targets for immune responses was initially surprising, an improved understanding of the pathway of antigen presentation to class I-restricted CTl provided the conceptual basis for the recognition of internal viral proteins (YEWDELL and BENNINK 1992) .
Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections by M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)
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