By C. B. Anfinsen

ISBN-10: 0120587513

ISBN-13: 9780120587513

ISBN-10: 0323140785

ISBN-13: 9780323140782

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P r o c . N a t . A c a d . S e i . USA 7 £ , 8 3 0 ( 1 9 7 3 ) . 5 4. P o t t s , J . T . , B e r g e r , Α . , Cooke, J . B. A r e i n v e s t i g a t i o n of t h e s e q u e n c e of r e s i d u e s 1 1 t o 18 i n b o v i n e p a n c r e a t i c r i b o n u c l e a s e . J . B i o l . C h e m . 23Z> 1 8 5 1 ( 1 9 6 2 ) . , unpublished and H A R O L D Α. S C H E R A G A 55. W. C o r r e l a t i o n between the t i o n of a m i n o a c i d s and a l p h a h e l i c e s . J5, 3 6 7 ( 1 9 6 6 ) .

6_, 1 0 3 ( 1 9 6 8 ) . 60. Scheraga, New Y o r k , 61. A. S t r u c t u r a l s t u d i e s of p a n c r e a t i c ribonuclease. F e d . P r o c . , 1 3 8 0 ( 1 9 6 7 ) . 62. A. Theoretical s t u d i e s of c o n f o r m a t i o n s of R e v s . 7 1 , 195 ( 1 9 7 1 ) . 63. S c h e r a g a , H . A . , L e w i s , P . N . , M o m a n y , F . A . , Von D r e e l e , P . H . W. a n d H o w a r d , J . C . H a i r p i n bends i n o l i g o p e p t i d e s and p r o t e i n s . F e d . P r o c . 3 2 , 495 ( 1 9 7 3 ) .

The o r i g i n a l h y p o t h e s i s was t h e r e f o r e m o d i f i e d by s u g g e s t i n g t h a t one i s d e a l i n g w i t h two forms of t h e m o n o m e r . One f o r m , " m o n o m e r X , " w a s v i s u a l i z e d a s t h e a c t i v e form of t h e e n z y m e , a n d t h e i n a c t i v e form was t e r m e d "monomer Y . " However X a p p a r e n t l y has " s t i c k y " s u r f a c e s which could a t t a c h to each o t h e r , w h i l e monomer Y was n o t c a p a b l e of p o l y m e r i z i n g .

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