By Jiro J Kaneko
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Additional info for Clinical Biochemistry of Domestic Animals
Specific gravity is a measure of the concentration of solids in the urine. These are principally the cations (sodium, potassium, and ammonium) and their anions (phosphate, sulfate, bicarbonate, and chloride) and urea. The observed specific gravity of urine is the result of the additive effect of the contributions of each (Price et al, 1940). 004 units for each gm/100 ml. 010 unit. Therefore, while specific gravity is a valuable measure of renal function, it is of little value with respect to the glycosuria of diabetes, except, of course, in extreme glycosurias.
This occurs partially as a mass action effect and results in an inflow of glucose into the tissues. Thus, the diabetic animal con tinues to utilize glucose in the absence of insulin but only at the expense of increased glucose production and hyperglycemia. A s the deficiency of insulin progressively becomes more severe, the equilibrium level of blood glucose is established at higher and higher levels and equilibrium may never be established. Blood glucose values in canine diabetes have been reported as high as 1250 mg% (Wilkinson, 1960).
Little is known of the genetic aspects of diabetes in animals as compared to man, in which the hereditary predisposition is well known. Diabetes has, however, been reported in the female offspring of a diabetic bitch (Roberts, 1954). The recent finding of hereditary diabetes in a laboratory animal, the Chinese hamster (Meier and Yerganian, 1959), should have important consequences in the study of the nature of the disease. Contributory factors to the onset of the disease most often mentioned are pancreatitis, obesity, infection, stress, and estrum (Wilkinson, I960).
Clinical Biochemistry of Domestic Animals by Jiro J Kaneko
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