By Herman Friedman, Yoshimasa Yamamoto, Mauro Bendinelli
Chlamydia pneumoniae is a micro organism that's most typically identified for inflicting colds and pneumonia. even if, researchers have lately came across a hyperlink among C. pneumoniae and atherosclerosis, a clogging of the arteries that factors center assault and stroke. moreover, ongoing learn is displaying that convinced lines may perhaps play a task in bronchial asthma, a number of sclerosis, Alzheimer's disorder, and arthritis.
This quantity, a part of the Infectious brokers and Pathogenesis sequence, is an entire portrait of C. pneumoniae and what's at the moment identified approximately it.
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1995, Inhibition of Chlamydia pneumoniae growth in HEp-2 cells pretreated with gamma interferon and tumor necrosis factor alpha, Infect. Immun, 63:2801–2803. 35. , Hudson, A. , 2000, Persistent of Chlamydia trachomatis is induced by ciprofloxacin in vitro, Antimicrob. Agents Chemother. 44:3288–3297. 36. , and Manire, G. , 1970, Electron microscopic observations on the effects of penicillin on the morphology of Chlamydia psittaci, J. Bacteriol. 101:278–285. 37. , Pogson, C. , Jones, M. , and Pearce, J.
Many B structures are seen (arrowheads). Bars indicate FIGURE 11. Freeze-replica images of an in situ chlamydial inclusion membrane containing the Chlamydia pneumoniae. KKpn-15 strain at 60 h after infection. Fine particles in groups are indicated by arrowheads. The face is rugged over the RB outline (inset). Bars indicate MORPHOLOGY OF C. (28) demonstrated that C. psittaci and C. (29) It is likely that the chlamydiae use an alternate secretory pathway, a type III secretion pathway. The surface projections are, therefore, possible candidates for that function.
Both micrographs show hexagonally arrayed projections in a limited area of the surface. Bars indicate 300 nm. outer membrane is mediated by surface projections, but these projections have not been visualized because of inadequate opacity in thin sections prepared by ordinary procedures. This supposition is supported by evidence that the projections are located in a group on a limited surface area (Fig. (1) By the freeze-replica technique, in situ inclusions at the late stage of multiplication are visualized as convex and concave faces (Fig.
Chlamydia pneumoniae: infection and disease by Herman Friedman, Yoshimasa Yamamoto, Mauro Bendinelli
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