By Kevin Strange (auth.), Kevin Strange (eds.)

ISBN-10: 1588295974

ISBN-13: 9781588295972

ISBN-10: 1597451517

ISBN-13: 9781597451512

Molecular biology has pushed a robust reductionist, or “molecule-c- tric,” method of organic learn within the final half the 20 th century. crimson- tionism is the try and clarify advanced phenomena by means of defining the practical houses of the person elements of the approach. Bloom (1) has stated the post-genome sequencing period because the finish of “naïve reductionism. ” crimson- tionist equipment will remain a vital component of all organic study efforts, yet “naïve reductionism,” the assumption that reductionism on my own can result in an entire realizing of residing organisms, isn't really tenable. Organisms are truly even more than the sum in their components, and the habit of advanced physiological procedures can't be understood just by figuring out how the elements paintings in isolation. structures biology has emerged within the wake of genome sequencing because the s- cessor to reductionism (2–5). The “systems” of structures biology are outlined over a large span of complexity starting from macromolecules that engage to hold out a selected activity to complete organisms. platforms biology is integrative and seeks to appreciate and expect the habit or “emergent” houses of advanced, multicomponent organic procedures. A systems-level characteri- tion of a organic strategy addresses the next 3 major questions: (1) What are the elements of the method (i. e.

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Table 1 lists the 26 18 C. briggsae C. elegans Result of χ2 test Cluster function 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 299 268 224 163 230 222 122 97 14 88 93 102 80 103 97 94 91 87 96 88 73 78 72 62 74 10 275 284 266 312 184 19 116 141 211 137 111 96 117 94 89 92 90 94 80 79 82 70 70 80 67 130 Not significant Not significant Not significant Significant Not significant Significant Not significant Significant Significant Significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Not significant Significant Protein kinase Transcription factor, zinc finger 7TM subfamily 1 7TM subfamily 2 EGF-like Unknown function BTB/POZ Serpentine receptor (some are pseudogenes) F-box/FTH Lectin Unknown: DUF216 Cuticle collagen Tyrosine specific protein phosphatase Neurotransmitter-gated ion-channel ligand binding domain Myosin G protein β WD-40 repeat UDP-glucoronosyl/UDP-glucosyl transferase Protein kinase Transcription factor, zinc finger RNA binding protein Cytochrome P450 Cuticle collagen Ras GTPase Lectin Rhodopsin-like GPCR superfamily (serpentine receptor) F-box a Found using TRIBE-MCL (29).

Shabalina, S. , Ogurtsov, A. , and Kondrashov, A. S. (2002) 31. Analysis of similarity within 142 pairs of orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae. Nucleic Acids Res. 30, 1233–1239. , Kent, W. , et al. (2003) Human-mouse alignments with 32. BLASTZ. Genome Res. 13, 103–107. , Mesirov, J. , and Lander, E. S. (2000) 33. Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res. 10, 950–958. 34 34. , and Mango, S.

Org/db/searches/class_query. 3. Object Identifiers All objects in WormBase drawn from the AceDB database have an associated class and name. To discover the class of a particular object, search for it from the main page using the “Anything” option. The class and name will be displayed in the URL. For most classes, object names correlate with the most common name of the object itself. Recently, however, WormBase has moved towards serialized identifiers for a number of classes. This makes data management and versioning substantially easier and allows for distinct objects to have the same public name.

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