By Meir Shinitzky

ISBN-10: 3527300228

ISBN-13: 9783527300228

ISBN-10: 352761611X

ISBN-13: 9783527616114

An up-to date evaluate of uncomplicated examine on biomembranes. during this quantity, premier specialists within the box ponder an important structural and sensible points of biomembranes: - Membrane Lipids and Aging
- Membrane-bound Enzymes
- Ion Channels in organic Membranes
- Anion Exchangers of Mammalian telephone Membranes
- variety of delivery Mechanisms in Bacteria.

the amount is a superb complement to 'Biomembranes - actual Aspects', additionally edited by way of Meir Shinitzky. jointly those books supply a entire floor for knowing advanced physiological processes.
Meir Shinitzky, Ph.D., is a Professor of Biophysics within the division of Membrane learn and Biophysics, The Weizmann Institute of technological know-how, Rehovot, Israel. because 1971, his examine has occupied with quite a few facets of membrane constitution and dynamics. presently his major curiosity is in manipulation of membrane fluidity for medical diagnoses and coverings. He has released commonly and is said around the world as one of many major specialists within the more and more major box of biomembrane learn.

Content:
Chapter 1 Membrane Lipids and getting older (pages 1–82): Hilary R. Shmeeda, Elisabeth B. Golden and Yechexkel Barenholz
Chapter 2 Membrane?Bound Enzymes (pages 83–197): G. Lenaz and M. Degli Esposti
Chapter three Ion Channels in organic Membranes – common ideas (pages 199–296): Rami Rahamimoff, Simona Ginsburg, Gavriel Barkai, Boaz cook dinner, Jackie Edry?Schiller, Igor Kaiserman, Alon Meir, Michal Roll, Mary Kate Worden and Nilly Yakir
Chapter four Anion Exchangers of Mammalian mobile Membranes (pages 297–327): Z. Ioav Cabantchik
Chapter five range of delivery Mechanisms in micro organism (pages 329–379): Bert Poolman, Douwe Molenaar and Wil N. Konings

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Van Lenten and Roheim [454], however, reported no change in rat plasma cholesterol with age. In humans, changes in serum cholesterol levels upon aging display a complex profile. Average male serum cholesterol levels increase continuously from age 20-50 y, plateau for a short period and then decline. Average female serum cholesterol levels are lower initially but increase to reach the male value by age 50 and thereafter exceed that of males, peaking at age 60, then decreasing (data from Tecumesh Michigan Study; see review by [ 1641).

Block and coworkers have evidence that low concentrations of LDL can elicit PI turnover and cellular activation in a variety of cell types [36]. The close correlation between LDL-dependent activation of PI turnover and uptake of LDL-Chol in these cells suggests that the PI cycle may be involved in cellular regulation of cholesterol metabolism. Sphingosine and lysosphingolipids, breakdown products of SPM, have been shown recently to be biologically active, affecting cellular responses and may be involved in signal transduction (review by [150,267]).

The phospholipid increase is due mainly to a rise in one phospholipid, phosphatidylcholine. It has been suggested that independent transfer of PC is followed by equilibrium partitioning with the cholesterol and PL of LDL. The increased transfer of PC may be related to the elevated PL/protein ratio of LDL in these patients. A metabolic interrelationship between the level of SPM and cholesterol in plasma membranes was proposed originally by Patton [307] and may be related to their parallel increase in aging systems.

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