By R. D. Sinelnikov and Ludmila Aksenova

ISBN-10: 5030003223

ISBN-13: 9785030003221

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Additional info for Atlas of Human Anatomy vol.III-Nervous System, Endocrine Glands And Sense Organs

Example text

Either endogenous or exogenous substances can be studied. In this chapter, the focus is on the study of the rate and/or extent of transport of exogenous compounds such as drugs across the BBB. In many cases, these same methods can be used for studying endogenous compounds. This chapter will therefore outline the available in vivo and in situ methods of assessing BBB function, listing some of their specific properties. The pharmacokinetic principles behind the BBB transport of drugs are presented first, followed by discussion of the various methods and the properties of BBB transport that each illustrates.

Pharm Res 20:618–623 41. Dagenais C, Graff CL, Pollack GM (2004) Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol 67:269–276 42. Tunblad K, Hammarlund-Udenaes M, Jonsson EN (2005) Influence of probenecid on the delivery of morphine-6-glucuronide to the brain. Eur J Pharm Sci 24:49–57 43. Ohno K, Pettigrew KD, Rapoport SI (1978) Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am J Physiol 235:H299–H307 44. Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.

Dahlin AP, Hjort K, Hillered L, Sjodin MO, Bergquist J, Wetterhall M (2012) Multiplexed quantification of proteins adsorbed to surface-modified and non-modified microdialysis membranes. Anal Bioanal Chem 402:2057–2067 75. Gazzin S, Strazielle N, Schmitt C, Fevre-Montange M, Ostrow JD, Tiribelli C, Ghersi-Egea JF (2008) Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood–brain interfaces. J Comp Neurol 510:497–507 76. Westerhout J, Ploeger B, Smeets J, Danhof M, de Lange EC (2012) Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.

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Atlas of Human Anatomy vol.III-Nervous System, Endocrine Glands And Sense Organs by R. D. Sinelnikov and Ludmila Aksenova


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