By Robert L. LaFemina

ISBN-10: 1555814395

ISBN-13: 9781555814397

ISBN-10: 1555815499

ISBN-13: 9781555815493

Captures the country of the technology with twenty stories that learn the newest in today’s antiviral drug discovery efforts.

  • Presents the elemental rules of antiviral brokers and forecasts destiny possibilities.
  • Investigates novel enzyme and protein inhibitors.
  • Analyzes medical elements of viral an infection in regards to remedy and toxicity.
  • Examines recognized and power ambitions in any respect phases of viral improvement.
  • Serves as a source for virologists, biochemists, pharmaceutical chemists, and different investigators.
  • Covers a huge diversity of viruses, together with HIV-1, HSV, and HCV.

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Herpes simplex virus type 1 DNA polymerase. Mechanism of inhibition by acyclovir triphosphate. J. Biol. Chem. 264:7405–7411. 129. Reichman, R. , G. J. Badger, G. J. Mertz, L. Corey, D. D. Richman, J. D. Connor, D. Redfield, M. C. Savoia, M. N. Oxman, and Y. Bryson. 1984. Treatment of recurrent genital herpes simplex infections with oral acyclovir. A controlled trial. JAMA 251:2103–2107. 130. , E. C. Mar, E. S. Huang, and M. D. Topal. 1988. Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human alpha and human beta polymerases.

W. , D. Hinthorn, C. Liu, R. B. Pollard, F. Hayden, G. J. Mertz, M. Oxman, and S. J. Soong. 1992. Disseminated herpes zoster in the immunocompromised host: a comparative trial of acyclovir and vidarabine. The NIAID Collaborative Antiviral Study Group. J. Infect. Dis. 165:450–455. 158. Whitley, R. , A. J. Nahmias, S. J. Soong, G. G. Galasso, C. L. Fleming, and C. A. Alford. 1980. Vidarabine therapy of neonatal herpes simplex virus infection. Pediatrics 66:495–501. 159. Whitley, R. , S. J. Soong, R.

Littler. 1995. A comparative study of the in vitro and in vivo antiviral activities of aciclovir and penciclovir. Antivir. Chem. Chemother. 6:89–97. 51. Field, H. J. 1982. Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy. Antimicrob. Agents Chemother. 21:744–752. 52. Field, H. , and E. Lay. 1984. Characterization of latent infections in mice inoculated with herpes simplex virus which is clinically resistant to acyclovir. Antivir. Res. 4:43–52.

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Antiviral research : strategies in antiviral drug discovery by Robert L. LaFemina

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