By Paul F. Torrence

ISBN-10: 0471668273

ISBN-13: 9780471668275

ISBN-10: 0471716707

ISBN-13: 9780471716709

Antiviral Drug Discovery provides readers a state of the art view of the way chemical options are being mobilized to increase novel ways that might successfully confront rising illnesses and biowarfare. one of the subject matters mentioned are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. every one bankruptcy discusses hypothetical ideas for the invention of suitable antiviral brokers, contemporary findings with regards to biochemistry or drug discovery, and advances within the additional improvement of tested leads within the zone. well timed and informative, this publication basically delineates the efforts being made to enhance new and powerful broad-spectrum antiviral brokers.

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Extra resources for Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats

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Fortunately, drug development also provides a model for defense against acute illness caused by airborne viruses, in the form of aerosolized (zanamivir) and oral medications (oseltamivir, amantadine) for the prevention and Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats. Edited by Paul F. Torrence Copyright # 2005 John Wiley & Sons, Inc. 2 Self-administration of one of these drugs, beginning before or after exposure to a flu patient, can protect against the initiation of infection, restrict viral dissemination, and block further transmission.

In Textbook of Military Medicine, Office of the Surgeon General, Department of the Army, Washington, DC, 1997, pp. 561–589. 13. ; Handelman, S. Biohazard. Random House, New York, 1999. 14. ; Buller, R. M. L. Looking back at smallpox. Clin. Infect. Dis. 2004, 38, 882–890. 15. Basler, C. ; Klenk, H. ; Palese, P. The Ebola virus VP35 protein functions as a type I IFN antagonist. Proc. Natl. Acad. Sci. USA 2000, 97, 12289–12294. 16. Basler, C. ; Klenk, H. ; Garcia-Sastre, A. The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

Y. Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney. Antiviral Res. 2003, 59,163–171. 35. Bray. ; Huggins, J. W. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus infection. J. Infect. Dis. 2000, 181, 10–19. 36. ; De Clercq, E. Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993, 22, 45–75. 37. ; Paragas, J. Experimental therapy of filovirus infections. Antiviral Res.

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Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats by Paul F. Torrence


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